How Long to Bake Turkey Tenderloin at 350 Degrees for Juicy, Tender Meat

Turkey tenderloin is a lean tender cut of meat that can make for a delicious and healthy dinner option. When baked properly turkey tenderloin emerges from the oven juicy, flavorful and perfectly cooked. One of the keys to cooking turkey tenderloin is using the right temperature – too low and it won’t cook through, too high and it will dry out. For most tenderloins, 350 degrees Fahrenheit is the ideal baking temperature. But how long should you bake turkey tenderloin at 350 degrees?

How Long to Bake a Turkey Tenderloin Depends on Weight

The exact baking time depends on the size and weight of the turkey tenderloin. Here are general guidelines

• 12 oz tenderloin – bake at 350°F for 30-35 minutes
• 1 lb tenderloin – bake at 350°F for 35-40 minutes
• 1.5 lb tenderloin – bake at 350°F for 45-50 minutes
• 2 lb tenderloin – bake at 350°F for 50-55 minutes

For an accurate baking time, use an instant read meat thermometer. Turkey is safe to eat once it reaches an internal temperature of 165°F.

Tips for Baked Turkey Tenderloin

Follow these tips for tender, juicy turkey tenderloin baked at 350 degrees

1. Brine the Tenderloin

Soaking the tenderloin in a saltwater brine before baking helps season the meat and keeps it moist during cooking. Dissolve 1/2 cup salt in 4 cups water and submerge the tenderloin for 30 minutes up to 8 hours. Rinse and pat dry before baking.

2. Use a Meat Thermometer

This ensures the tenderloin bakes long enough to reach a safe 165°F internal temperature. Insert into the thickest part without touching bone.

3. Allow the Tenderloin to Rest

Letting it rest for 5-10 minutes after baking allows the juices to reabsorb back into the meat. Tent loosely with foil to keep warm.

4. Sear Before Baking

Briefly searing the tenderloin in a hot pan before putting it in the oven enhances the flavor and browns the outside.

5. Add Herbs and Spices

Coat the tenderloin with olive oil and season generously with herbs like rosemary, thyme and sage. Other good seasonings include garlic, citrus zest, paprika or cumin.

6. Roast on a Rack

Placing the tenderloin on a rack elevated over a baking sheet allows air circulation for even cooking.

Step-By-Step Instructions

Follow these simple steps for juicy turkey tenderloin baked at 350°F:

1. Prepare the Tenderloin

Rinse the tenderloin under cold water and pat dry completely with paper towels. Trim off any excess fat or silver skin. If brining, submerge in brine for 30 minutes to 8 hours, rinse and pat very dry.

2. Preheat the Oven

Preheat your oven to 350°F. Be sure to give it plenty of time to fully preheat before baking.

3. Season the Tenderloin

Coat the tenderloin all over with olive oil or melted butter. Season generously with desired herbs, spices, salt and pepper. Rub the seasonings into the meat.

4. Sear (Optional)

For enhanced flavor, you can sear the seasoned tenderloin in a hot skillet for 1-2 minutes per side to brown it.

5. Roast on a Rack

Place a wire rack over a rimmed baking sheet. Set the seasoned tenderloin on the rack. This elevates it for air circulation.

6. Bake Until 165°F

Bake for 30-55 minutes depending on weight until it reaches an internal temp of 165°F. Use an instant read thermometer to test.

7. Allow to Rest

Remove tenderloin from the oven, tent loosely with foil and allow to rest 5-10 minutes before slicing.

8. Slice and Serve

Slice the rested turkey tenderloin into medallions. Serve warm.

Cooking Turkey Tenderloin in the Oven

Baking turkey tenderloin at 350°F yields tender, juicy results every time. Allowing 30-55 minutes of cooking time depending on the weight ensures it reaches a safe internal temperature of 165°F. Be sure to always use a meat thermometer for accurately cooked poultry. Resting the tenderloin after baking allows the juices to redistribute evenly. Slice and serve this healthy turkey dish hot alongside your favorite sides for an easy weeknight meal.