Lyrica (pregabalin) is an FDA-approved anti-seizure medication prescribed to treat several conditions including epilepsy, fibromyalgia, and nerve pain. It is a commonly prescribed pain medication in the United States, with over 64 million prescriptions dispensed in 2016.1 Lyrica slows the brain impulses associated with seizures by calming hyperactive neurons and treats pain from nerve damage by altering the chemicals involved in pain signals.2 Lyrica is a GABA analogue that falls into the anticonvulsant class of medications.
Some people who take Lyrica feel that the medication induces a state similar to being drunk, while other common side effects include:3
The half-life of Lyrica is approximately 6 hours, and withdrawal symptoms may start within 24 hours after the last dose is taken. Immediate Lyrica withdrawal symptoms usually last for about 1-2 days, while residual symptoms can last for several weeks.
In many cases, you may become dependent on Lyrica and experience withdrawal effects after using the drug for an extended period. Those abusing the drug should slowly taper off Lyrica to prevent the more severe side effects of withdrawal, which can be quite uncomfortable. Sometimes these symptoms may be life-threatening and require medical care.
Lyrica, also known by its generic name pregabalin, is an anticonvulsant medication used to treat nerve pain associated with diabetic neuropathy, postherpetic neuralgia, fibromyalgia, and spinal cord injury. It is also used together with other medications to treat certain types of seizures.
While Lyrica can be highly effective in managing nerve pain and seizure disorders, some people decide to stop taking it, with or without medical advice This raises the question – is it safe to stop Lyrica suddenly, or do you have to slowly taper it? Let’s take a detailed look at whether it’s possible to quit Lyrica cold turkey
How Lyrica Works
To understand what happens when you stop Lyrica suddenly it’s important to first understand how it works.
Lyrica binds to calcium channels in the brain and spinal cord, reducing abnormal electrical activity that leads to seizures and nerve pain signals. This helps calm overly excited nerves.
When you take Lyrica regularly for an extended period, your body gets used to having the drug around. If you suddenly stop it, your nerves can become overexcited again, leading to withdrawal effects.
Is Stopping Lyrica Cold Turkey Dangerous?
Most doctors recommend tapering Lyrica dosage slowly rather than quitting cold turkey. This is because suddenly stopping Lyrica can cause uncomfortable and even dangerous withdrawal symptoms.
Potential Lyrica withdrawal side effects include:
- Headaches
- Nausea
- Diarrhea
- Insomnia
- Anxiety
- Sweating
- Tremors
- Seizures (if taken for epilepsy)
Seizures are the most serious potential consequence of abruptly stopping Lyrica. Even if you don’t have epilepsy, sudden Lyrica cessation can trigger seizure activity in the brain.
Other typical Lyrica withdrawal symptoms like headaches, nausea, diarrhea, and anxiety tend to be milder but can still significantly impact quality of life.
When Is It Okay to Stop Lyrica Suddenly?
While most people should taper Lyrica slowly under medical supervision, there are some circumstances where it may be appropriate to stop it abruptly:
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If you experience a severe allergic reaction to Lyrica such as swelling, rash, or trouble breathing, discontinue it immediately and seek emergency care.
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If you develop severe side effects like angioedema (swelling under the skin), stop taking Lyrica right away and call your doctor.
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If your doctor instructs you to stop Lyrica due to intolerable side effects or other medical reasons, follow their directives.
In these cases, the risks of continuing to take Lyrica likely outweigh the risks of sudden discontinuation. Your doctor can guide you through safely transitioning off if needed.
How to Safely Taper Lyrica
When Lyrica needs to be discontinued, doctors typically recommend a gradual taper to allow your body to adjust to lower dosages slowly. This helps minimize withdrawal discomfort.
There is no set protocol for tapering Lyrica, but some general guidelines include:
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Reduce your dosage by 25-50mg every 1-2 weeks, depending on your starting dosage.
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If you experience significant withdrawal symptoms, slow down the taper. Do not increase your dosage.
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The entire tapering process may take 4 weeks or longer to finish, based on your individual situation.
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Never cut extended-release Lyrica CR capsules or tablets – be sure to taper with regular Lyrica.
Your doctor can provide you with a customized Lyrica discontinuation schedule to make the process as smooth as possible.
Can You Reinstate and Taper Again If Withdrawal Is Severe?
Some people find Lyrica withdrawal symptoms intolerable even with gradual tapering. In this case, you may need to temporarily reinstate your previous dosage to provide relief, then try tapering more slowly.
For example, if you cut your dose in half and experience severe headaches and nausea, you could go back to your full dose for 1-2 weeks to stabilize. Then try tapering by 25mg every 3-4 weeks instead.
Work closely with your doctor to find the ideal taper rate that minimizes Lyrica withdrawal discomfort for you. Be patient – you may need to adjust the pace a few times to get it right.
Helpful Tips for Quitting Lyrica Successfully
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Consult your doctor about using other medications short-term to manage Lyrica withdrawal symptoms like headaches, anxiety, and sleep disruption.
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Stay hydrated and eat a balanced diet throughout the taper process. Proper nutrition can help minimize side effects.
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Ask your pharmacist about liquid formulations of Lyrica that allow smaller dose reductions.
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Consider counseling or peer support groups to help cope with uncertainties around discontinuing Lyrica.
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Avoid driving or operating heavy machinery as you taper Lyrica, since dizziness is common.
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Use relaxation techniques like meditation, yoga, or deep breathing exercises to stay calm.
With careful planning, ongoing medical supervision, and self-care during the taper process, most people can successfully transition off of Lyrica. Be patient with yourself and don’t hesitate to get help if you struggle. You’ve got this!
When to Call Your Doctor During the Lyrica Taper
Notify your healthcare provider right away if you experience any of the following during your Lyrica taper:
- Suicidal thoughts
- Signs of angioedema like swelling of the face, mouth, hands or feet
- Shortness of breath or difficulty breathing
- Uncontrolled shaking or tremors
- Hallucinations or confusion
- Multiple or severe seizures if you have epilepsy
Your doctor may be able to adjust your taper plan to address concerning symptoms. But sometimes symptoms are severe enough that resuming your previous higher Lyrica dosage, adding supplemental medication, or even inpatient medical treatment may be required for safety.
Seeking Help for Lyrica Withdrawal
Quitting Lyrica can be challenging both physically and emotionally, especially if you’ve taken it for an extended period. Don’t hesitate to enlist help.
Your healthcare providers can offer medical advice and support, and prescribe other medications to ease specific withdrawal symptoms if appropriate. Counseling provides problem-solving, encouragement and skills for coping with the process.
Peer support groups connect you with others who have been through Lyrica withdrawal and can offer real-world tips. Online forums like Drugs.com allow you to ask questions and get feedback from people who understand exactly what you’re dealing with.
You may also want to look into rehabilitation programs that specialize in safely tapering people off medications like Lyrica under medical supervision. Having knowledgeable professionals oversee the process can offer significant peace of mind.
The important thing is that you don’t have to do this alone – support and help are available. Taking advantage of resources can make a successful Lyrica taper far more achievable.
The Bottom Line
While stopping Lyrica cold turkey is not recommended in most cases due to potential withdrawal symptoms and complications, there are some situations where abrupt discontinuation may be warranted – but always check with your doctor first. For planned Lyrica cessation, work with your healthcare provider to slowly taper your dosage over weeks or months to avoid side effects. With medical guidance and support, most people can successfully transition off Lyrica. Be patient, take care of yourself and don’t hesitate to ask for help.
Lyrica Withdrawal Detox Treatment
If you are seeking help for an addiction to Lyrica, a detox program can be extremely beneficial. Look for a professional detox facility that provides a medically assisted withdrawal protocol will help drug abusers to avoid some of the harsher symptoms of withdrawal during detox. There are also several medications available that may be prescribed by an addiction treatment specialist for easing the withdrawal symptoms associated with Lyrica addiction, including benzodiazepines and clonidine.10 After completion of detox, it is important to participate in a formal addiction treatment program such as behavioral therapy.
How Addictive is Lyrica?
The DEA classified Lyrica as a schedule V drug, meaning that it is in the lowest class for abuse. However, this does not mean that Lyrica can’t be addictive and abuse-forming in certain people.
There has been a rapid increase in the recreational abuse of Lyrica in recent years. Users find that they can experience euphoria and feelings of dissociation when they exceed normal therapeutic dosages or use alternative routes of administration, such as inhalation or injection.7 A study published in Emergency Medicine Journal reports a rising number of patients arriving at emergency rooms with adverse symptoms stemming from Lyrica abuse. Several patients presented with seizures while some required intubation and ventilation prior to being admitted to the intensive care unit.8 There is also evidence that taking Lyrica together with other drugs increases the risk of mortality. One study found that Lyrica significantly increased the risk of acute overdose death when combined with opiates such as heroin.9
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Can You Stop Lyrica Cold Turkey
FAQ
What are the guidelines for reducing pregabalin?
What happens if you forget to take pregabalin?
What happens to your body when you stop taking gabapentin?
What happens when you stop taking the drug?
Does Lyrica have withdrawal symptoms?
Unfortunately many doctors aren’t even aware that there are withdrawal symptoms associated with Lyrica. This leads to them telling patients that it’s fine to discontinue the drug “cold turkey.” Those who quit the drug abruptly or “cold turkey” tend to have longer lasting withdrawals with more severe symptoms than those who conduct a gradual taper.
Should I taper off Lyrica?
Users should slowly taper off Lyrica under the care of a medical professional. This is to ease the intensity of the symptoms of withdrawal from Lyrica. 5 As mentioned above, the duration of detox may be more pronounced or prolonged in people who have used large amounts or who have taken Lyrica over an extended period of time.
Does Lyrica have side effects?
May be used in the management of fibromyalgia. Appears to have few drug interactions, although a compounding of side effects (such as sedation) may be seen if Lyrica is used with other drugs with similar side effects. Lyrica is available as a generic under the name pregabalin. 3. Downsides
What happens if you stop using Lyrica?
Since Lyrica can be used to manage seizures, abruptly stopping the medication can lead to a recurrence of seizures, which can be fatal. Overdose. Similar to other drugs, rapidly stopping use of Lyrica can lead to strong cravings and relapse, which can increase the likelihood of overdose. Suicidal thoughts.